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What is PGx?

Pharmacogenomics, or PGx, is the study of how medications work in our bodies based on our genetic makeup.

Each person has a different code and different genome, which means each person has different responses to medications - pharmacogenomics takes some of the guesswork out of choosing medications for patients by looking at their gene profiles and deciphering how medications will be processed.

Who can benefit from PGx?

  • Patients who have not had an adequate response or treatment failure to psychiatric medications
    (varies by lab and may include CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, UGT1A4, UGT2B15)
  • Patients with cancer that could benefit from targeted therapy agents (EGFR, BRAF, HER2)
  • Patients taking clopidogrel (CYP2C19)
  • Patients taking warfarin for anticoagulation (CYP2C9 and VKORC1)
  • Patients taking statin medications with muscle aches (SLC01B1)
  • Patients on HIV therapy, particularly abacavir (HLA-B)

How is PGx done?

  • A provider will write a prescription for the pharmacogenomic test.
  • The sample for testing is typically collected using a cheek cell sample via mouth swab.
    • Once the sample is collected, it will be sent to a pharmacogenomic lab to be processed.
  • Also collected using a blood sample.
  • Your healthcare provider will send in the sample to the lab to have your results interpreted. They will provide a report back to you that will be explained by your healthcare provider.


 Get your free copy of the Chart of CPIC Actionable Guidelines for Common Medications